I'm new to this, but I'm looking to add 2 10's to my 2013 Ford F-250 4 door and It seems as if JL audio or memphis 10's would be my best bet? Thoughts?

 

if you listen to the trance music memphis subwoofer could be a good choice.
but in my opinion jl audio is the best brand to buy car subwoofer.

 

that makes no sense at all. It all comes down to the enclosure. The gear used is only 25% of the results you will get.

Why are JL and Memphis your only options??? There are tons of great brands out there which generally are higher quality for cheaper than these two brands.

Also need to know which model of each brand you're considering....otherwise you're basically asking "Should I buy an audi or bmw?" it completely depends on the model etc.