New set up suggestions
 

Looking to get myself into a new setup for my new vehicle. It's an 03 F250. Not looking for something tooo extreme. Right now, I have a 880PRS as my head unit. Looking to get a set of two way components up front, and possibly a sub in the back to run actively. Open to suggestions on where to start to build a decent SQ on a budget.

Well, I'll give you my two cents. Keep the change. :)

I'm not certain what your budget is, but I'll make a suggestion for your sub and amp.
Amplifier >>> Cadence XaH175.4B link.
The amp will supply 110W RMS x 2 into 4 ohms for your front stage, and 350W RMS after bridging the rear channels for your subwoofer.

Subwoofer>>> Cadence S1W10-D4 link.

I have the 8" version of this exact subwoofer. I built a very small sealed box for it, and it's getting its power at 300W @ 4 ohm from a monoblock Kenwood amp. I love how clean this subwoofer sounds. The RMS for the 8" is 250W, so I'm overpowering it, but my amp settings are reduced to compensate.

I'd HIGHLY recommend the 10" version of that sub. When I bought mine, OCS (Online Car Stereo) didn't carry this particular sub (I think they're a new product), so I ordered it from another site. I paid $90 for the 8", before shipping and taxes. The only reason I am suggesting the 10" instead of the 8", is to match the RMS of sub handling to amp output.

As for the front components, strictly basing this on matching RMS handling and output, I'd suggest these:

Alpine SPR-60C <<< Link.

Rockford Fosgate T1652-S <<< Link...

Cerwin Vega V-Max 65 <<< Link.

Hopefully other start to chime in and either agree, or disagree with my suggestions.

Suggested System
Focal Ps165 299.99
Jl Audio Jx360/4 250.00
Jl Audio 10W3 250.00
Atrend Enclosure 149.00