I've heard cases where people have ran speaker wire close to power wire with no issues. I'm running 4g power wire andd 14g speaker wire along the ds door jam. Do I have to worry about any unnessarry engine noise or any other issues?

 

Shouldn't have any problems with that.

 

When doing a mono and 4 channel install I always put power on one side rca and speaker wire on the other ( of the car) but only cause I have a hard time fitting all the wire down one jam,

 

Install is a 07 Toyota Tacoma. I'm using 14g CL2 rated speaker wire. I will be running the power wire along ds to the rear centre where it will be connected to distribution block. From distru block will branch two ways. First, under driver side seat where 4 ch amp will be mounted and under passenger side seat will be 2 ch amp. My front door speakers will be replaced with components and rear access doors w coaxial. Speaker wires will come out of doors and run to rear storage compartments where crossovers will be mounted. RCA and remote wire will be run along center console.

 

It's power and RCAs together that can cause problems.....power and speaker wire, not so much.....

HTH